VIP / Vasoactive Intestinal Peptide (5mg Research Vial)
Analytical Standards & Laboratory Handling
Verified laboratory protocols, reconstitution parameters, and handling guidelines.
Pharmacological Profile & Mechanism of Action
What it is: VIP is a 28-amino-acid endogenous neuropeptide belonging to the glucagon/secretin superfamily, functioning as a primary neuromodulator and anti-inflammatory neurotrophic factor.
How it works: VIP binds with high nanomolar affinity to VPAC1 and VPAC2 G-protein-coupled receptors, driving intracellular cAMP accumulation, stabilizing pulmonary arterial pressure, suppressing microglial pro-inflammatory cytokines, and restoring circadian rhythm synchronization in the suprachiasmatic nucleus.
Why researchers study it: Researched in neuroinflammation, chronic inflammatory response syndrome (CIRS), pulmonary arterial hypertension, and autoimmune central nervous system models.




