Pinealon
Analytical Standards & Laboratory Handling
Verified laboratory protocols, reconstitution parameters, and handling guidelines.
Pharmacological Profile & Mechanism of Action
What it is: Pinealon is a synthetic neuroprotective tripeptide composed of L-glutamic acid, L-arginine, and L-aspartic acid (Glu-Arg-Asp / E-R-D), modeled after natural bioregulatory peptides isolated from the pineal gland and cerebral cortex.
How it works: Pinealon penetrates cell and nuclear membranes directly, interacting with histone proteins to modulate gene expression in brain tissue. It stimulates ribosomal RNA transcription, activates endogenous antioxidant enzymes (superoxide dismutase and catalase), and prevents caspase-3-mediated apoptotic cell death induced by oxidative stress, hypoxia, or aging.
Why researchers study it: Studied for cerebral vascular health, circadian rhythm synchronization, cognitive preservation in extreme environments, protecting neurons against ischemic insults, and reducing intellectual fatigue.
