SHLP-2 (10mg Research Vial)
Analytical Standards & Laboratory Handling
Verified laboratory protocols, reconstitution parameters, and handling guidelines.
Pharmacological Profile & Mechanism of Action
What it is: SHLP-2 is a 26-amino-acid peptide encoded by an open reading frame within the 16S ribosomal RNA gene of the mitochondrial genome, functioning as a mitochondrial-derived hormone.
How it works: SHLP-2 enhances mitochondrial oxygen consumption rate (OCR), reduces reactive oxygen species (ROS) production, stimulates peripheral insulin sensitivity via hypothalamic ERK phosphorylation, and protects pancreatic beta-cells from cytokine apoptosis.
Why researchers study it: Researched in metabolic longevity, type 2 diabetes insulin sensitization, and preventing neurodegenerative mitochondrial collapse.




