Cardiogen (20mg Khavinson Bioregulator)
Analytical Standards & Laboratory Handling
Verified laboratory protocols, reconstitution parameters, and handling guidelines.
Pharmacological Profile & Mechanism of Action
What it is: Cardiogen is a synthetic Khavinson tetrapeptide (Ala-Glu-Asp-Arg) specifically targeted at myocardial tissue and cardiac fibroblasts. It regulates extracellular matrix turnover and supports cardiomyocyte metabolic resilience.
How it works: AEDR diffuses into cardiomyocyte nuclei to modulate genes governing myocardial contractility. It modulates the Bcl-2/Bax expression ratio, inhibits caspase-3 cleavage under hypoxia-reoxygenation, and stabilizes connexin-43 (Cx43) distribution at intercalated discs while suppressing excess TGF-beta1-mediated fibrotic collagen deposition.
Why researchers study it: Used to study myocardial protection during ischemia-reperfusion models, post-infarction fibrotic remodeling, cardiomyocyte longevity, and gap-junction electrophysiological stability.
