BAM15 (25mg Research Vial)
Analytical Standards & Laboratory Handling
Verified laboratory protocols, reconstitution parameters, and handling guidelines.
Pharmacological Profile & Mechanism of Action
What it is: BAM15 (N5,N6-bis(2-fluorophenyl)-[1,2,5]oxadiazolo[3,4-b]pyrazine-5,6-diamine) is a synthetic mitochondrial protonophore uncoupler, structurally engineered to bypass the systemic toxicity of older uncouplers like DNP.
How it works: BAM15 specifically depolarizes the inner mitochondrial membrane to uncouple oxidative phosphorylation from ATP synthesis without depolarizing the plasma membrane or causing cellular hyperthermia, dissipating energy as heat and burning lipid stores.
Why researchers study it: Researched in preclinical obesity, insulin resistance, hepatic steatosis, and cardiac ischemia-reperfusion models.




