Ace-031 / ActRIIB-Fc (1mg Research Vial)
Analytical Standards & Laboratory Handling
Verified laboratory protocols, reconstitution parameters, and handling guidelines.
Pharmacological Profile & Mechanism of Action
What it is: Ace-031 is an engineered soluble decoy receptor consisting of the extracellular ligand-binding domain of human activin receptor type IIB (ActRIIB) fused to the Fc portion of human IgG1.
How it works: By binding tightly to circulating myostatin, GDF-11, and activins, Ace-031 prevents these inhibitory ligands from interacting with cellular cell-surface ActRIIB receptors, driving pronounced lean muscle mass gains.
Why researchers study it: Researched in Phase 1/2 human clinical trials for Duchenne muscular dystrophy and ambulatory muscle preservation.




