Pentosan Polysulfate Sodium
Laboratory Consumable Specifications
Certified for Precision Research & Preparation Procedures
Analytical Standards & Laboratory Handling
Verified laboratory protocols, reconstitution parameters, and handling guidelines.
Pharmacological Profile & Mechanism of Action
What it is: Pentosan Polysulfate Sodium (PPS) is a semi-synthetic macromolecular carbohydrate polymer derived from beechwood hemicellulose, bearing structural similarities to glycosaminoglycans.
How it works: PPS acts as a chondroprotective agent that protects joint cartilage. It inhibits cartilage-degrading enzymes (like ADAMTS-5 and MMP-13), stimulates hyaluronic acid synthesis in synovial fluid, improves subchondral bone microcirculation, and reduces bone marrow edema.
Why researchers study it: Studied for osteoarthritis, degenerative joint disease, cartilage rebuilding, interstitial cystitis, and restoring fluid lubrication to arthritic joints.
