MOTS-C
Analytical Standards & Laboratory Handling
Verified laboratory protocols, reconstitution parameters, and handling guidelines.
Pharmacological Profile & Mechanism of Action
What it is: MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a groundbreaking 16-amino-acid mitochondrial-derived peptide encoded directly within mitochondrial DNA.
How it works: It acts as a powerful cellular exercise mimetic. When cells experience metabolic stress, MOTS-c translocates to the nucleus to regulate gene expression and activates AMPK (AMP-activated protein kinase). This turns on the folate-methionine cycle, stimulates glucose uptake into skeletal muscles without requiring insulin, and shifts cellular metabolism toward fat burning.
Why researchers study it: Researched for reversing insulin resistance, combating obesity, increasing physical endurance and stamina, extending cellular lifespan, and preserving muscle metabolism during aging.
