5-Amino-1MQ
Analytical Standards & Laboratory Handling
Verified laboratory protocols, reconstitution parameters, and handling guidelines.
Pharmacological Profile & Mechanism of Action
What it is: 5-Amino-1MQ is a small-molecule chemical compound that acts as a selective, membrane-permeable inhibitor of NNMT (Nicotinamide N-methyltransferase), an enzyme overexpressed in fat tissue of obese individuals.
How it works: By blocking NNMT, 5-Amino-1MQ stops the wasteful methylation of nicotinamide. This dramatically boosts intracellular NAD+ levels and SAM (S-adenosylmethionine) concentrations, which in turn revs up SIRT1 longevity enzymes and turns white fat cells into active, fat-burning metabolic furnaces without affecting the central nervous system.
Why researchers study it: Researched for cellular energy enhancement, reversing diet-induced obesity, preventing muscle atrophy, improving muscle stem cell function, and boosting mitochondrial longevity.




