Cotadutide (10mg Research Vial)
Analytical Standards & Laboratory Handling
Verified laboratory protocols, reconstitution parameters, and handling guidelines.
Pharmacological Profile & Mechanism of Action
What it is: Cotadutide (MEDI0382) is a potent synthetic oxyntomodulin-like peptide engineered with balanced dual agonism at both GLP-1 and glucagon receptors, conjugated with a palmitoyl fatty acid chain for extended half-life.
How it works: By engaging both GLP-1R and GCGR, Cotadutide stimulates insulin release, delays gastric emptying, improves whole-body energy expenditure, and promotes renal hemodynamic preservation in models of diabetic nephropathy.
Why researchers study it: Studied in Phase 2 clinical trials for type 2 diabetes with chronic kidney disease (CKD) and non-alcoholic fatty liver disease.




