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← Back to ProtocolsProtocol: melatonin-10mg

Validated Laboratory Standard

Chronobiology & Free Radical Biology RegistriesSingle Peptide

Melatonin

Revision 1 · Lyophilized Solid Powder

Research-Grade N-Acetyl-5-Methoxytryptamine Lyophilized Hormone. Formulated for in-vitro research and laboratory analytical validation.

In-Vitro Reference Standard · Verified Stoichiometry

✓GLP Analytical Monograph & Pharmacological Dossier

Melatonin

Research-Grade N-Acetyl-5-Methoxytryptamine Lyophilized Hormone. Formulated for in-vitro research and laboratory analytical validation.

≥99.0% (RP-HPLC)Cognitive & Neuroprotective

Pharmacokinetic & Bio-Distribution Parameters (ADME)

Elimination Half-Life (t½)~30 to 45 MinutesTypical protocol duration: 4 to 12 Weeks; Washout: 2 Weeks

Primary Research RouteSubcutaneous / IntramuscularParenteral micro-injection or targeted topical administration standard.

Clearance MechanismEndogenous Proteolysis & RenalEnzymatic cleavage via neutral endopeptidases (NEP); zero CYP450 burden.

Obs. Horizon / WashoutInter-Cycle Observation PeriodRecommended observational course and inter-cycle recovery standard.

Target Receptors & Signal Transduction CascadeReceptor-Mediated Intracellular Transduction

RUO Analytical Standard

Detailed GLP Pharmacological Monograph

Analytical Specification

Melatonin (N-acetyl-5-methoxytryptamine) is a high-purity research-grade lyophilized indolamine neurohormone synthesized endogenously by the pineal gland. Serving as the primary circadian chronobiological pacemaker via high-affinity MT1 and MT2 G-protein coupled receptors, Melatonin also functions as an exceptionally potent direct scavenger of reactive oxygen and nitrogen species, crossing blood-brain and mitochondrial membranes to protect electron transport complexes.

Investigated Pharmacodynamic Endpoints & Cellular Mechanisms

Preclinical Assays

✓

Mitochondrial Free-Radical Scavenging: Crosses blood-brain and mitochondrial membranes to neutralize hydroxyl radicals.

✓

Circadian Chronobiotic Phase Shifting: Synchronizes suprachiasmatic nucleus (SCN) master clock oscillations.

Physicochemical Specifications & Analytical Verification

≥99.0% (RP-HPLC)

CAS Number73-31-4

PubChem CIDCID 896 ↗

Molecular Weight232.28 g/mol

Primary Sequence / Chemical Formula

C13H16N2O2

Target Solvent

Bacteriostatic Water (0.9% Benzyl Alcohol)

Store refrigerated

Diluent Ratio

2 mL per 10 mg (5 mg/mL)

Slow laminar stream against vial wall; protect strictly from light.

Lyophilized Storage

Store at -20°C in amber container.

Desiccated and protected from thermal spikes

Liquid Stability

Store at 2°C–8°C.

Refrigerated and light-protected

Pharmacokinetics / Half-Life

~30 to 45 Minutes

Typical protocol duration: 4 to 12 Weeks; Washout: 2 Weeks

Preparation, Reconstitution & Syringe Calibration Matrix

Analytical Reference Standard

Select Vial Strength & Volume Configuration:

Dual Reconstitution Standard (10 mg Vial):

Stoichiometric Laboratory Protocol Flow

1. Lyophilized Cake10 mg Active MassVacuum-sealed vial

2. Aseptic Diluent2.0 mL DiluentSlowly down vial wall

3. Reconstituted Solution5.0 mg/mLGentle circular swirl

4. Calibrated DrawU-100 (100 units = 1.0 mL)1 unit = 50.0 mcg (0.01 mL)

Standard Compound Mass	10 mg active per vial
Recommended Diluent	Bacteriostatic Water (0.9% Benzyl Alcohol)
Diluent Volume Added	2.0 mL
Resulting Concentration	5.0 mg/mL
Syringe Volumetric Scale	U-100 Syringe (100 units = 1.0 mL \| 1 unit = 50.0 mcg (0.01 mL))

Interactive Syringe Calibration & Reconstitution Stoichiometry— Melatonin

Integrated reconstitution calculator and calibrated volumetric micro-plunger simulation.

⏱ 1x DailyU-100 Micro-Plunger

1. Compound Mass10 mg

Vials:

2. Diluent Volume2.0 mL

Quick:

3. Target Assay Dose20.0 Units

Presets:

Dissolution Vial

10mg / 2mL

Syringe: 100 U (1.0 mL Workhorse)

20.0 Units (0.200 mL)

0 U100 U

💡Micro-Dose Accuracy: Low draw (20.0 U). A 30 U (0.3 mL) barrel provides 3× optical tick resolution.

Selected Dose

1 mg

1000 µg active mass

Injection Volume

0.200 mL

200 µL draw

U-100 Syringe Mark

20.0 Units

Barrel Graduation

Single Vial Yield

~10.0 Doses

10 days at 1x Daily

Clinical Trial Titration & Escalation Schedules

Benchmark protocols from peer-reviewed clinical trials & institutional investigational programs.

Analytical Titration Schedule•Target: Melatonin•1x Daily

Escalation Stage & Phase	Target Dose	U-100 Mark (10mg / 2.0mL)	Cadence
In-Vitro Assay Titration Schedule (Weeks 1–2)	500 mcg	10.0 Units(0.10 mL)	1x Daily
In-Vitro Assay Titration Schedule (Weeks 3–6)	1 mg	20.0 Units(0.20 mL)	1x Daily
In-Vitro Assay Titration Schedule (Weeks 7+)	2 mg	40.0 Units(0.40 mL)	1x Daily

Reagent & Consumables Supply Inventory PlanningBased on 10mg vial strength & Analytical Titration Schedule

12-Week Initiation & Escalation CycleTotal: 17.0 mg

Active Vials (10mg):2 vials

Sterile Syringes:12 U-100

BAC Water (10mL):1 bottles

Alcohol Swabs:24 pads

24-Week Comprehensive Extended CycleTotal: 41.0 mg

Active Vials (10mg):5 vials

Sterile Syringes:24 U-100

BAC Water (10mL):1 bottles

Alcohol Swabs:48 pads

Standard U-100 Insulin Syringe (100 units = 1.0 mL)

Target: 20.0 Units (0.20 mL)

Research Dose	Volume (mL)	U-100 Syringe Graduation Mark
500 mcg	0.10 mL	10 Units 10 units
1,000 mcg	0.20 mL	20 Units 20 units
2,000 mcg	0.40 mL	40 Units 40 units

Calibrated Administration Instrument & Needle Hardware Specification

RUO Standard

Aliquoting Needle

Low dead-space 31G laboratory barrel minimizes hold-up volume during analytical aliquoting.

Hub & Dead Space Retention

Ultra-low dead space prevents peptide loss

Recommended Precision Barrel

High-resolution micro-dose calibrations

Reconstitution Transfer Needle

Sterile diluent transfer down glass wall

U-100 Insulin Syringe (0.3 mL, 31G)

Target: 20.0 IU = 1.0 mg at 5.0 mg/mL

Research Dose	Calibrated Volume	U-100 Syringe Units	Graduation Description
500 mcg	0.1 mL (100 µL)	10 Units	10 units
1,000 mcg	0.2 mL (200 µL)	20 Units	20 units
2,000 mcg	0.4 mL (400 µL)	40 Units	40 units

💉

Syringe Barrel Resolution & Dead-Space Calculator

ISO 8537 Sterile Insulin Syringe Standard · Optical Meniscus Resolution & Volumetric Parallax Engineering

10 U-100 Units (0.1 mL)

🎚️ Interactive Plunger Calibration Scrubber:

Mass @ 5.0 mg/mL:500 mcg

1 Unit (0.01 mL)25 Units50 Units (0.50 mL)75 Units100 Units (1.00 mL)

Optical Meniscus & Plunger Seal Alignment:0.3 mL Barrel Standard

✓ Exact Tick Mark Alignment (10 Units)

Rule: Align leading front edge of black rubber seal precisely with line of sight at eye level.Current Fill: 33.3% of barrel

Tick Increment

0.5 Unit (5 µL)

Volumetric step

Low-Dead-Space (LDS)

<0.4 µL (0.4%)

Integrated needle waste

Measurement Error

±1.5%

ISO 8537 tolerance

Needle Configuration

31G (0.26mm)

5/16" (8mm) length

⚖️

Critical Dead-Space Compound Preservation Analysis (Melatonin)

Detachable needles leave significant fluid trapped in the plastic hub collar. In peptide protocols, this causes substantial loss of active ingredient per administration.

Integrated Fixed-Needle (LDS)RECOMMENDED

Residual Hub Volume:< 0.4 µL

Wastage per Titration:0.4% of dose

84-Day Cumulative Loss:0.168 mg

Standard Detachable Luer-LockSEVERE LOSS HAZARD

Residual Hub Volume:~55 µL

Wastage per Titration:35.5% of dose

84-Day Cumulative Loss:23.1 mg (Multiple Vials!)

Barrel Capacity	Graduation Interval	Volume per Tick	Hub Dead-Space	Needle Spec	Suitability for 10 Units
0.3 mL (30 Units)BEST FIT	0.5 Unit	5 µL (0.005 mL)	< 0.4 µL	31G × 5/16" (8mm) Integrated Ultra-Fine	✓ Accommodates 10 units
0.5 mL (50 Units)	1 Unit	10 µL (0.010 mL)	< 0.8 µL	30G–31G × 5/16" (8mm) Integrated	✓ Accommodates 10 units
1 mL (100 Units)	2 Unit	20 µL (0.020 mL)	< 2.1 µL	29G–30G × 1/2" (12.7mm) Integrated	✓ Accommodates 10 units

📏 Parallax Error Elimination SOP

Viewing the syringe from an angle introduces a 1.0–2.5 unit parallax error. Always raise the barrel to direct eye level against a high-contrast white background. Align the front edge of the top black plunger seal ring with the target line.

📐 Analytical Dispensing Angle & Vessel Depth

Standard 5/16" (8mm) laboratory dispensing needles are calibrated for direct 90° fluid transfer into target analytical matrix vials. If utilizing 1/2" (12.7mm) cannulas in deep laboratory vessels, introduce at a 45° angle to avoid contact with vessel sidewalls.

12-Week Clinical Research Supply & Protocol Forecast

Stoichiometric supply planning, sequential reconstitution cadence, and itemized consumables BOM for Melatonin.

Planned Lyophilized Vial Mass:

Active Compound

119.00 mg

Across 12 weeks (84 doses)

Vials Required

13 × 10mg

Includes 8% dead-space buffer

Bacteriostatic Water

1 × 30 mL Multi-Dose Bottle

26.0 mL total diluent

Sterile Syringes

101 Units

U-100 LDS with fixed needle

Alcohol Prep Pads

202 Pads

70% Isopropyl Aseptic

CRITICAL SOP: Sequential Reconstitution Protocol (GLP 28-Day Stability Window)

Do NOT reconstitute all 13 vials simultaneously. Reconstitute one vial at a time as the active protocol requires. Once reconstituted with Bacteriostatic Water USP, a vial maintains stability for 28 days at +2°C to +8°C. Remaining unopened vials should be preserved in solid lyophilized cake form at -20°C to prevent hydrolysis and oxidation.

Week	Study / Assay Phase	Weekly Target Dose	Syringe Draw (U-100)	Active Vial #	Cumulative Active Mass
Week 1	Circadian Priming (Weeks 1–2)	500 mcg(7x/wk)	10 Units(0.10 mL)	Vial #1(6.5mg rem)	3.5 mg / 119.0 mg
Week 2	Circadian Priming (Weeks 1–2)	500 mcg(7x/wk)	10 Units(0.10 mL)	Vial #1(3mg rem)	7.0 mg / 119.0 mg
Week 3	Target Antioxidant (Weeks 3–6)	1.0 mg(7x/wk)	20 Units(0.20 mL)	Vial #2(3mg rem)	14.0 mg / 119.0 mg
Week 4	Target Antioxidant (Weeks 3–6)	1.0 mg(7x/wk)	20 Units(0.20 mL)	Vial #3(3mg rem)	21.0 mg / 119.0 mg
Week 5	Target Antioxidant (Weeks 3–6)	1.0 mg(7x/wk)	20 Units(0.20 mL)	Vial #4(3mg rem)	28.0 mg / 119.0 mg
Week 6	Target Antioxidant (Weeks 3–6)	1.0 mg(7x/wk)	20 Units(0.20 mL)	Vial #5(3mg rem)	35.0 mg / 119.0 mg
Week 7	High Exposure (Weeks 7+)	2.0 mg(7x/wk)	40 Units(0.40 mL)	Vial #6(0mg rem)	49.0 mg / 119.0 mg
Week 8	High Exposure (Weeks 7+)	2.0 mg(7x/wk)	40 Units(0.40 mL)	Vial #7(0mg rem)	63.0 mg / 119.0 mg
Week 9	High Exposure (Weeks 7+)	2.0 mg(7x/wk)	40 Units(0.40 mL)	Vial #8(0mg rem)	77.0 mg / 119.0 mg
Week 10	High Exposure (Weeks 7+)	2.0 mg(7x/wk)	40 Units(0.40 mL)	Vial #9(0mg rem)	91.0 mg / 119.0 mg
Week 11	High Exposure (Weeks 7+)	2.0 mg(7x/wk)	40 Units(0.40 mL)	Vial #10(0mg rem)	105.0 mg / 119.0 mg
Week 12	High Exposure (Weeks 7+)	2.0 mg(7x/wk)	40 Units(0.40 mL)	Vial #11(0mg rem)	119.0 mg / 119.0 mg

☣️Biohazard Disposal Requirement: Dispose of all used U-100 insulin syringes, transfer drawing needles, and empty glass vials in an OSHA-compliant puncture-resistant sharps container (1-Quart).

OSHA 1910.1030

In-Vitro Assay Titration Schedule

Assay Schedule

Study duration: 4 to 12 Weeks · Washout: 2 Weeks

Period / Phase	Target Amount	Frequency	Notes & Calibration
Weeks 1–2Starting Baseline	500 mcg	Nightly	Circadian Priming: MT1/MT2 receptor phase shifts (10 units on U-100 syringe)
Weeks 3–6	1 mg	Nightly	Target Antioxidant: Mitochondrial reactive species scavenging (20 units on U-100 syringe)
Weeks 7+	2 mg	Nightly	High Exposure: Neuroprotective chronobiology assay (40 units on U-100 syringe)

Investigated Research Endpoints & Observed Mechanisms

Biological Properties

✓Mitochondrial Free-Radical Scavenging: Crosses blood-brain and mitochondrial membranes to neutralize hydroxyl radicals.

✓Circadian Chronobiotic Phase Shifting: Synchronizes suprachiasmatic nucleus (SCN) master clock oscillations.

Adverse Observations, Handling Precautions & In-Vitro Sensitivities

Laboratory Safety Notes

!Daytime Drowsiness: If administered outside physiological circadian sleep windows.

Preparation and Handling SOP

Aseptic reconstitution in a certified laminar airflow hood utilizing sterile disposable syringes and Bacteriostatic Water (0.9% Benzyl Alcohol). Slow laminar stream against vial wall; protect strictly from light.

Physicochemical Stability & Reconstituted Storage

Environmental Guidelines

Lyophilized Solid Powder

Store at -20°C in amber container.

Reconstituted Solution

Store at 2°C–8°C.

[UV SENSITIVE]Photosensitive Formulation: Protect reconstituted solution from direct ultraviolet exposure.

🌡️

Physicochemical Thermostability & Environmental Tolerance Matrix

4-phase stability timeline, RP-HPLC degradation benchmarks, and storage SOPs for Melatonin

USP <659> Packaging & Storage

💧

Phase 3: Reconstituted Refrigerated Storage (2°C–8°C)

Operating Window: +2°C to +8°C (36°F to 46°F)

State: Reconstituted Solution28 to 35 Days

Active working solution dissolved in Bacteriostatic Water USP (0.9% Benzyl Alcohol).

Target Temperature

+2°C to +8°C

Maximum Duration

28 to 35 Days

Integrity Profile

Active

Analytical Handling Standard Operating Procedures:

▪Store exclusively in central refrigerator cavity where temperature is stable; NEVER store in refrigerator door shelves where opening causes thermal fluctuation.
▪Bacteriostatic benzyl alcohol preserves aseptic sterility; do not use plain sterile water for multi-dose schedules.
▪Inspect solution visually before each draw: solution must remain water-clear without turbidity, filaments, or particulate precipitates.

Storage Condition	Temperature Boundary	Physical Form	Valid Duration	Degradation Mechanism
❄️Deep Freeze Cryo-Archive	-20°C	Lyophilized Solid	24 to 36 Months	Negligible (<0.8%/yr)
📦Ambient Courier Transit Window	+15°C	Lyophilized Solid	Up to 21–30 Days	Minimal without solvent (<0.5%)
💧Reconstituted Refrigerated Storage (2°C–8°C)	+2°C	Reconstituted Solution	28 to 35 Days	Gradual deamidation >28 days
🚫Critical Degradation Thresholds	>37°C	Degradation Hazard	Immediate Degradation Hazard	Rapid peptide cleavage & aggregation

☀️

Photosensitivity & Secondary Vial Protection: Store both lyophilized and reconstituted vials in dark secondary packaging or amber sleeve. Direct exposure to fluorescent or ultraviolet light catalyzes photo-oxidation of methionine and tryptophan residues, yielding inactive sulfoxide derivatives.

Storage and Biohazard Disposal

Store at Store at -20°C in amber container.. Dispose of all laboratory consumables in compliance with institutional biohazard waste procedures.

Scholarly Research Citations (1 References)

Peer-Reviewed Index

Reiter RJ, et al. Melatonin: a versatile antioxidant and neuroprotective agent (Ann N Y Acad Sci 2004).↗ PubMed

PMID: 15649727

Verified scientific reference.

Frequently Asked Questions

How should Melatonin be reconstituted?

Slow laminar stream against vial wall; protect strictly from light.

What is the estimated laboratory half-life of Melatonin?

Melatonin displays an estimated half-life of ~30 to 45 Minutes. Typical study protocols run for 4 to 12 Weeks followed by a washout period of 2 Weeks.

Pharmacological Profile and Mechanism

Aseptic Reconstitution Procedure

1. Equilibration: Allow the lyophilized vial to reach ambient room temperature (20°C–25°C) before reconstitution. 2. Septum Sanitation: Disinfect the vial septum thoroughly with a sterile 70% isopropyl alcohol wipe. 3. Diluent Addition: Using a sterile syringe, slowly draw 2 mL of Bacteriostatic Water (0.9% Benzyl Alcohol). Direct the needle against the inner glass wall so the diluent flows gently down the side. 4. Gentle Dissolution: Slow laminar stream against vial wall; protect strictly from light. 5. Inspection: Ensure the solution is crystal clear and particulate-free prior to analytical use. undefined

Storage and Temperature Stability

Lyophilized powder: Store at -20°C in amber container.. Once reconstituted: Store at 2°C–8°C.. Keep shielded from UV light.

Physicochemical Specifications

CAS Number: 73-31-4 PubChem CID: 896 Formula/Sequence: C13H16N2O2 Molecular Weight: 232.28 g/mol

In-Vitro Concentration & Assay Schedule

• Circadian Priming (Weeks 1–2): Target Assay Dose: 500 mcg nightly | Cadence: Nightly Assay Focus: MT1/MT2 receptor phase shifts Volumetric Calibration: 10 units on U-100 syringe • Target Antioxidant (Weeks 3–6): Target Assay Dose: 1,000 mcg nightly | Cadence: Nightly Assay Focus: Mitochondrial reactive species scavenging Volumetric Calibration: 20 units on U-100 syringe • High Exposure (Weeks 7+): Target Assay Dose: 2,000 mcg nightly | Cadence: Nightly Assay Focus: Neuroprotective chronobiology assay Volumetric Calibration: 40 units on U-100 syringe Typical Study Duration: 4 to 12 Weeks Receptor Washout Window: 2 Weeks

Available in Catalog

Melatonin (10mg Research Grade Lyophilized)

High-purity lyophilized laboratory reference formulation with certified Certificate of Analysis (COA).

View Product in Catalog →

Strictly for in vitro and academic laboratory research purposes only. Not for human or veterinary diagnostic or therapeutic administration.

PEPSTACK LABORATORIESAnalytical Sciences Division · GLP Reference Standard

Melatonin

Standard Lyophilized Monograph

Doc ID: PSL-SOP-MELATONIN1-REV1Rev: 1Category: Cognitive & NeuroprotectiveDate: September 29, 2026

QR CODE

Verify Lot COApepstacklabs.com/ph/research-protocols/melatonin-10mg

Pharmacological Profile & Monograph

Research-Grade N-Acetyl-5-Methoxytryptamine Lyophilized Hormone. Formulated for in-vitro research and laboratory analytical validation.

Investigated Research Endpoints

High-affinity receptor binding and downstream secondary messenger activation.
Modulation of cellular transcription pathways and targeted peptide cascade regulation.
Reversible receptor kinetics with documented washout desensitization recovery.

Molecular & Biochemical Identity

Chemical Name:Melatonin

CAS Registry Number:73-31-4

PubChem CID:896

Molecular Weight:232.28 g/mol

Quality Standard:Reference Standard Grade

Physical Appearance:Sterile Lyophilized Solid Cake

Sequence/Formula:C13H16N2O2

Critical Laboratory Storage & Handling Directive:

Store desiccated at -20°C upon receipt. Reconstitute strictly in a certified laminar airflow hood utilizing sterile disposable instruments. Avoid direct exposure to UV or fluorescent radiation.

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Master Volumetric Reconstitution Matrix & Diluent Ratios

Net Active Mass	Target Solvent	Diluent Volume	Resulting Concentration	Syringe Graduation Scale
10 mg Lyophilized Cake	Bacteriostatic Water USP (0.9% Benzyl Alcohol)	2.0 mL	5.00 mg/mL	1 Unit = 50.0 mcg (0.01 mL)

Calibrated U-100 Laboratory Syringe Barrel (30 U / 0.3 mL)Target Mark: 10.0 Units (0.100 mL)

0 U (Resting Plunger)Align leading front edge of black stopper to 10.0 Units (0.100 mL)30 U (0.3 mL)

ISO 8537 Standard Barrel Resolution & Precision MatrixTolerance: ±1.5%

0.3 mL Syringe (30 Units)0.5 Unit (5 µL) GraduationOptimal for Doses ≤25 Units

0.5 mL Syringe (50 Units)1.0 Unit (10 µL) GraduationSuitable for 25–45 Units

1.0 mL Syringe (100 Units)2.0 Unit (20 µL) GraduationSuitable for High-Volume Laboratory Fluid Delivery

4-Step Laminar Flow Hood Reconstitution SOP:

1. Sanitize & Inspect

Swab vial septum with sterile 70% IPA pad. Inspect cake for vacuum seal integrity.

2. Slow Wall Influx

Introduce 2.0 mL solvent slowly down inner glass wall. Never spray directly on cake.

3. Horizontal Swirl

Swirl gently in horizontal circles until fully dissolved. Never shake or invert aggressively.

4. Resting Clarity

Rest at +2°C to +8°C for 10 minutes until solution is crystal clear before drawing.

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Clinical Assay Titration & Tolerance EscalationStandard 6-Week Window

Phase	Target Active Dose	U-100 Syringe Graduation	Cadence & Pharmacological Purpose
Days 1–7 (Priming)	500 mcg	10.0 Units (0.100 mL)	Initial receptor priming; evaluate baseline physiological tolerance.
Weeks 2–4 (Saturation)	750 mcg	15.0 Units (0.150 mL)	Target assay maintenance; peak neurotrophic / metabolic response.
Weeks 5–6 (Taper & Washout)	500 mcg	10.0 Units (0.100 mL)	Receptor consolidation prior to mandatory 4-week washout cycle.

Synchronized 7-Day Administration Timetable & Chronobiology

MONDosing Day08:00 AM

TUEDosing Day08:00 AM

WEDDosing Day08:00 AM

THUDosing Day08:00 AM

FRIDosing Day08:00 AM

SATOff-Cycle08:00 AM

SUNOff-Cycle08:00 AM

Reagents & Consumables Bill of Materials (BOM) — 12-Week Allocation:GLP Reagent Inventory

Peptide Vials3x 10mg Vials(Incl. 8% dead-space buffer)

Diluent Solvent2x 10 mL BAC WaterUSP 0.9% Benzyl Alcohol

Sterile Syringes1x Box (100 pcs)31G 5/16" Fixed LDS U-100

70% IPA Prep Pads1x Box (100 pcs)Sterile 2-ply isopropyl pads

☣️ OSHA 1910.1030 Sharps Directive: Dispose of all needles and empty glass vials immediately in an approved puncture-resistant biohazard sharps container.OSHA COMPLIANT

Laboratory Research Specification · In-Vitro Reference StandardVerification Ref: PSL-SOP-MELATONIN1-REV1

Analytical Assay Standard:

RP-HPLC / LC-MS In-Vitro Assay

Purity Spec: ≥ 98.0% Area

Regulatory Classification:

Research Use Only (RUO)

NOT EVALUATED OR APPROVED BY FDA

Validation Release Stamp:

ANALYTICAL REFERENCE GRADE · RUO VALIDATED

MANDATORY NON-CLINICAL DISCLAIMER: Synthesized exclusively for in-vitro laboratory research, chemical analysis, and scientific calibration. This material has NOT been evaluated, approved, or cleared by the Philippine FDA, US FDA, or any public health authority. Strictly NOT for human, veterinary, diagnostic, or therapeutic administration.

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