Melanotan II
Analytical Standards & Laboratory Handling
Verified laboratory protocols, reconstitution parameters, and handling guidelines.
Pharmacological Profile & Mechanism of Action
What it is: Melanotan II (MT-2) is a synthetic cyclic lactam heptapeptide analogue of alpha-Melanocyte-Stimulating Hormone (alpha-MSH).
How it works: Unlike Melanotan I, MT-2 is non-selective: it crosses the blood-brain barrier to bind to multiple melanocortin receptors, including MC1R (skin tanning), MC3R/MC4R (appetite suppression and metabolic regulation), and MC4R (sexual arousal and erectile response in the central nervous system).
Why researchers study it: Studied for rapid, deep photoprotective skin tanning, treating erectile dysfunction and female sexual arousal disorder, and appetite suppression.
Compound & Molecular Specifications
Certificate of Analysis StandardsFrequently Stacked with Melanotan II
Clinically verified combinations activating complementary physiological pathways without receptor competition.
PT-141 (Bremelanotide)
Melanotan II provides systemic melanin upregulation via MC1R/MC4R, while PT-141 (Bremelanotide) selectively acts centrally on hypothalamic MC4R to trigger rapid erectile and sexual arousal pathways without cardiovascular vasoconstriction.
