KPV
Analytical Standards & Laboratory Handling
Verified laboratory protocols, reconstitution parameters, and handling guidelines.
Pharmacological Profile & Mechanism of Action
What it is: KPV is a potent natural tripeptide (Lysine-Proline-Valine) representing the active C-terminal fragment of alpha-Melanocyte-Stimulating Hormone (alpha-MSH).
How it works: KPV enters the nucleus of cells and prevents the activation of NF-kB, the master switch of systemic inflammation, without triggering skin tanning or melanogenesis. In addition, KPV exhibits direct antimicrobial and antifungal properties by disrupting the cell walls of harmful microbes like Candida albicans and Staphylococcus aureus.
Why researchers study it: Studied primarily for inflammatory bowel diseases (Crohn's disease, ulcerative colitis), severe dermatological inflammation (eczema, psoriasis), mast cell activation, and gut microbiome balance.
